Anti-CD19/Anti-CD3/Anti-CD2 Trispecific Antibody PIT565

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A trispecific T-cell engager and antibody targeting the tumor-associated antigen (TAA) CD19, the T-cell surface antigen CD3, and the T-cell co-stimulatory receptor CD2, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD19/anti-CD3/anti-CD2 trispecific antibody PIT565 targets and binds to CD3 and CD2 on T-cells and CD19 expressed on tumor cells. The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response against CD19-expressing tumor cells. CD19 antigen is a B-cell specific cell surface antigen overexpressed in B-cell lineage malignancies.

**Synonyms:** - Anti-CD19/CD3/CD2 Trispecific Antibody PIT565 - CD19 x CD3 x CD2 Trispecific Antibody PIT565 - PIT 565 - PIT-565 - PIT565