Ismidenon

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable azaindolizinone derivative and acetylcholine releasing agent, with potential neurocognitive-enhancing activity. Upon oral administration, ismidenon increases acetylcholine release in the central nervous system (CNS), thereby enhancing cholinergic neurotransmission. Ismidenon also decreases amyloid beta peptide production. This may improve neurocognitive function in Alzheimer's disease.

**Synonyms:** - AD 101 - AD-101 - AD101 - Acetylcholine Releasing Agent ST101 - Acetylcholine Releasing Agent ZSET-1446 - ISMIDENON - ST 101 - ST-101 - ST101 - ZSET 1446 - ZSET-1446 - ZSET1446