KCNJ11 wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human KCNJ11 wild-type allele is located in the vicinity of 11p15.1 and is approximately 24 kb in length. This allele, which encodes ATP-sensitive inward rectifier potassium channel 11 protein, plays a role in potassium ion transport and in the regulation of insulin secretion. Mutations in the gene are associated with familial hyperinsulinemic hypoglycemia 2, maturity-onset diabetes of the young 13, transient neonatal diabetes mellitus 3, permanent neonatal diabetes 2, with or without neurologic features, and increased susceptibility to type 2 diabetes mellitus.

**Synonyms:** - BIR - Beta-Cell Inward Rectifier Gene - Beta-Cell Inward Rectifier Subunit Gene - HHF2 - IKATP - Inwardly Rectifing Potassium Channel Subfamily J Member 11 Gene - Inwardly Rectifying Potassium Channel KIR6.2 Gene - Inwardly-Rectifying Potassium Channel Subfamily J Member 11 Gene - KIR6.2 - MODY13 - PHHI - PNDM2 - Potassium Channel Inwardly Rectifing Subfamily J Member 11 Gene - Potassium Channel, Inwardly Rectifying, BIR Subunit Gene - Potassium Channel, Inwardly Rectifying, Subfamily J, Member 11 Gene - Potassium Inwardly Rectifying Channel Subfamily J Member 11 wt Allele - Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 Gene - Potassium Voltage-Gated Channel Subfamily J Member 11 Gene - TNDM3