CD33-specific CAR Lentiviral Vector-transduced Allogeneic T-lymphocytes

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of allogeneic T-lymphocytes transduced with a lentiviral vector expressing a chimeric antigen receptor (CAR) specific for the CD33 antigen, with potential immunomodulating and antineoplastic activities. Upon administration, CD33-specific CAR lentiviral vector-transduced allogeneic T-lymphocytes target and induce selective toxicity in CD33-expressing tumor cells. CD33 is expressed on normal non-pluripotent hematopoietic stem cells and on myeloid leukemia cells.

**Synonyms:** - Allogeneic Anti-CD33 Chimeric Antigen Receptor T Cells - Allogeneic CD33-CAR-T Cells - Allogneic Anti-CD33 CAR-T Cells