CD19-CD34tagged Metabolically Programmed CAR T-cells

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of a subset of T-lymphocytes, that are metabolically enhanced based on selection and purification on CD34 expression and primed to contain T-helper subset 1 and 17 (Th1/17 hybrid cells), that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) CD19, with potential immunostimulating and antineoplastic activities. Upon administration, CD19-CD34tagged metabolically programmed CAR T-cells target and bind to CD19-expressing tumor cells, thereby inducing selective toxicity in CD19-expressing tumor cells. CD19 is a B-cell specific cell surface antigen expressed in all B-cell lineage malignancies. These T-cells may show enhanced persistence and effector function as compared to other, non-metabolically enhanced, anti-CD19 CAR T-cells.

**Synonyms:** - Anti-CD19 CAR-expressing CD34tagged Metabolically Programmed T-cells - CD19-CD34t Metabolically Programmed CAR T-cells - CD34-selected Metabolically Fit CD19 CAR T Cells - Metabolically Programmed CD19 CAR-T Cells