Anti-EpCAM/Anti-CD3 Bispecific Antibody A-337

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A T-cell engager (TCE) and bispecific antibody composed of two fragments targeting the tumor-associated antigen (TAA) human epithelial cell adhesion molecule (Ep-CAM; EpCAM; CD326) and one targeting the T-cell surface glycoprotein CD3, with potential immunomodulating and antineoplastic activities. Upon administration, anti-EpCAM/anti-CD3 bispecific antibody A-337 targets and binds to EpCAM on EpCAM-expressing tumor cells and CD3 on cytotoxic T-lymphocytes (CTLs). This activates and redirects CTLs to EpCAM-expressing tumor cells, which results in the CTL-mediated cell death of EpCAM-expressing tumor cells. EpCAM, a cell surface protein upregulated on many tumor cell types, promotes the proliferation, migration and invasiveness of tumor cells.

**Synonyms:** - A 337 - A-337 - A337 - Anti-EpCAM/Anti-EpCAM/Anti-CD3 Bispecific Antibody A-337 - EpCAM x EpCAM x CD3 Bispecific Antibody A-337 - Itab A-337 - Recombinant Anti-EpCAM-CD3 Antibody A-337