Arlocabtagene Autoleucel

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) human G-protein coupled receptor family C group 5 member D (GPRC5D), with potential immunostimulating and antineoplastic activities. Upon leukapheresis, isolation, transduction, expansion ex vivo, and reintroduction into the patient, arlocabtagene autoleucel specifically recognizes and induces selective toxicity in GPRC5D-expressing tumor cells. GPRC5D is overexpressed in certain malignancies, such as multiple myeloma, while minimally expressed in normal, healthy cells. It plays a key role in tumor cell proliferation.

**Synonyms:** - ARLOCABTAGENE AUTOLEUCEL - Autologous Anti-GPRC5D CAR T-cells BMS-986393 - Autologous Anti-GPRC5D CAR-T Cells CC-95266 - BMS 986393 - BMS-986393 - BMS986393 - CC 95266 - CC-95266 - CC95266 - GPRC5D-targeted Autologous CAR T Cells BMS-986393