Imdatifan

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** An orally available inhibitor of hypoxia inducible factor (HIF)-2alpha, with potential antineoplastic activity. Upon oral administration, imdatifan targets and binds to HIF-2alpha, thereby preventing HIF-2alpha heterodimerization and its subsequent binding to DNA. This results in decreased transcription and expression of HIF-2alpha downstream target genes, many of which regulate tumor cell growth and survival. Blocking HIF-2alpha reduces the proliferation of HIF-2alpha-expressing tumor cells. HIF-2alpha, a heterodimeric transcription factor overexpressed in many cancer cell types, promotes proliferation, progression and metastasis of tumors.

**Synonyms:** - HIF-2alpha Inhibitor NKT 2152 - HIF2a Inhibitor NKT2152 - IMDATIFAN - NKT 2152 - NKT-2152 - NKT2152