Sacibertinib

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable, irreversible dual kinase inhibitor of epidermal growth factor receptor (EGFR; ErbB1) and human epidermal growth factor receptor 2 (HER2; EGFR2; ErbB2), with potential antineoplastic activity. Upon oral administration, sacibertinib covalently binds to and inhibits the activity of EGFR and HER2. This prevents EGFR/HER2-mediated signaling, which may induce cell death and inhibit tumor growth in EGFR/HER2-overexpressing tumor cells. The ErbB receptor tyrosine kinase family is involved in key cellular functions, including cell growth and survival. EGFR and HER2 alterations constitutively upregulate kinase activity.

**Synonyms:** - EGFR/HER2 Inhibitor Hemay022 - Hemay 022 - Hemay-022 - Hemay022 - SACIBERTINIB