Narmafotinib

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable inhibitor of focal adhesion kinase 1 (FAK1; FAK; protein tyrosine kinase 2; PTK2), with potential antineoplastic activity. Upon oral administration, narmafotinib targets and inhibits FAK. This prevents FAK-mediated downstream signaling and inhibits migration, proliferation, invasion, and survival in FAK-overexpressing tumor cells. FAK, a non-receptor tyrosine kinase overexpressed in various tumor cell types, is involved in tumor cell survival, proliferation, migration and chemoresistance.

**Synonyms:** - AMP 945 - AMP-945 - AMP945 - NARMAFOTINIB