Treatment Arm for COG ACNS0334 Combination Chemotherapy Followed By Peripheral Stem Cell Transplant in Treating Young Patients with Newly Diagnosed Supratentorial Primitive Neuroectodermal Tumors or High-Risk Medulloblastoma

**Semantic type:** Research Activity

**Definition:** A treatment arm associated with a phase III Children’s Oncology Group trial (ACNS0334) to establish if intensive chemotherapy plus high-dose methotrexate and peripheral blood stem cell rescue results in a higher complete response rate then the same regimen without methotrexate for treatment of infants with high risk primitive neuroectodermal tumors or high-risk medulloblastoma. (Lafay-Cousin L, et al. Cancers (Basel). 2022 Feb 7;14(3):837.)