ACNS0333 Arm II Includes Chemotherapy, 3D-CRT, Autologous PBSC

**Semantic type:** Research Activity

**Definition:** Patients received treatment in the following courses sequence: 1) Chemotherapy: Patients receive vincristine intravenously (IV) on days 1, 8, and 15; high-dose methotrexate IV on day 1; leucovorin calcium orally or IV; etoposide IV on days 4, 5, and 6; cyclophosphamide IV on days 4 and 5; cisplatin IV on day 6, and G-CSF IV or SC on day 7 until ANC recovers, 2) Patients undergo 3D-CRT to the brain (and the spine if needed) 5 days a week for 5-6 weeks, 3) Within 2-6 weeks after completion of radiation therapy, patients receive high-dose carboplatin IV and high-dose thiotepa IV on days 1 and 2 and undergo autologous peripheral blood stem cells (PBSC) rescue on approximately day 4. Patients also receive G-CSF IV or SC once daily until ANC recovers. Treatment repeats every 28 days for 3 courses in the absence of disease progression or unacceptable toxicity. (Reddy AT, et al. J Clin Oncol. 2020 Oct 1;38(28):3353-3354.)

**Synonyms:** - ACNS0333:Arm II (Chemotherapy, 3D-CRT, Autologous PBSC)