Glycoprotein Ib/IX Complex

**Semantic type:** Amino Acid, Peptide, or Protein

**Definition:** A heterotetrameric, transmembrane protein complex consisting of three subunits, platelet glycoprotein (GP) 1b alpha (GPIba), GP 1b beta (GPIbb), and GPIX, which are organized in the platelet membrane in a ratio of 1:2:1. The two GPIbb subunits form disulfide bonds with GPIba and are non-covalently linked to GPIX. This complex is involved in platelet biogenesis, thrombin-mediated platelet aggregation, vonWillebrand factor-mediated platelet adhesion, mechanotransduction, platelet activation and blood clot formation. Antibodies targeting this complex are associated with autoimmune thrombocytopenic purpura.

**Synonyms:** - CD42ABC Complex - Complex Glycoprotein Ib-IX - GPIb-IX - GPIb/IX - PLATELET GLYCOPROTEIN IB/IX - Platelet GPIb/IX - Platelet GPIb/Ix - Platelet Glycoprotein Ib-IX - Platelet Glycoprotein Ib/IX Complex