Androgen Receptor Degrader RO7656594

**Semantic type:** Pharmacologic Substance

**Definition:** An orally bioavailable androgen receptor (AR) degrader, with potential antineoplastic activity. Upon oral administration, AR degrader RO7656594 targets, binds to and degrades AR, thereby preventing AR-mediated signaling and inhibiting the proliferation of AR-overexpressing tumor cells. AR, a hormone-regulated transcription factor, plays a key role in tumor cell proliferation in castration-resistant prostate cancer (CRPC).

**Synonyms:** - AR Degrader RO7656594 - GDC 2992 - GDC-2992 - GDC2992 - RG 6537 - RG-6537 - RG6537 - RO 7656594 - RO-7656594 - RO7656594