MPZ wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human MPZ wild-type allele is located in the vicinity of 1q23.3 and is approximately 6 kb in length. This allele, which encodes myelin protein P0, is involved in the structural integrity of the peripheral myelin sheath. Mutation of the gene is associated with congenital hypomyelinating neuropathy 2, Dejerine-Sottas disease, Roussy-Levy syndrome and several forms of Charcot-Marie-Tooth disease, including dominant intermediate D, type 1B, type 2I and type 2J.

**Synonyms:** - CHM - CHN2 - CMT1 - CMT1B - CMT2I - CMT2J - CMT4E - CMTDI3 - CMTDID - Charcot-Marie-Tooth Neuropathy 1B Gene - DSS - HMSNIB - MPP - Myelin Protein Zero wt Allele - P0 - P0 Myelin Protein, Peripheral Gene