NDP wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human NDP wild-type allele is located in the vicinity of Xp11.3 and is approximately 25 kb in length. This allele, which encodes norrin protein, is involved in G protein-coupled receptor-dependent activation of the Wnt signaling pathway. Mutations in the gene are associated with Norrie disease and X-linked exudative vitreoretinopathy.

**Synonyms:** - EVR2 - Exudative Vitreoretinopathy 2 (X-Linked) Gene - FEVR - ND - NDP, Norrin Cystine Knot Growth Factor Gene - NORRIN - Norrie Disease (Pseudoglioma) Gene - Norrin Cystine Knot Growth Factor NDP wt Allele