Radicicol Derivative KF58333

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A novel oxime derivative of radicicol that destabilizes the hsp90 client proteins, such as erbB2, raf-1 and AKT, which are essential for tumor cell growth and survival. (NCI)

**Synonyms:** - (1aR,2Z,4E,6E,14R,15aR)-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione 6-[O-[2-(2-Oxo-1-pyrrolidinyl)ethyl]oxime] - (1aR,2Z,4E,6E,14R,15aR)-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione 6-[O-[2-(2-Oxo-1-pyrrolidinyl)ethyl]oxime] - KF-58333 - KF58333