RECIP 1.0 Progressive Disease

**Semantic type:** Intellectual Product

**Definition:** Greater than or equal to a 20% increase in prostate-specific membrane antigen (PSMA) volume with the appearance of new lesions. A new lesion is defined as any new focal uptake of PSMA ligand that is higher than the surrounding background, or where the tumor maximum standardized uptake value (SUVmax) is greater than blood pool SUVmax or that was not present on baseline scan (tumor SUVmax less than blood pool SUVmax), with tumor uptake not attributable to physiologic uptake or pitfalls, or any new malignant lesion detected on follow-up CT images independent of PSMA ligand uptake.

**Synonyms:** - Response Evaluation Criteria in Prostate-specific Membrane Antigen PET/CT 1.0 Progressive Disease