RECIP 1.0 Stable Disease

**Semantic type:** Intellectual Product

**Definition:** Less than 30% decrease in prostate-specific membrane antigen (PSMA) volume with or without the appearance of new lesions, or greater than or equal to a 30% decrease in PSMA volume with the appearance of new lesion(s), or less than a 20% increase in PSMA volume with or without the appearance of new lesions, or greater than or equal to a 20% increase in PSMA volume without the appearance of new lesions. A new lesion is defined as any new focal uptake of PSMA ligand that is higher than the surrounding background, or where the tumor maximum standardized uptake value (SUVmax) is greater than blood pool SUVmax or that was not present on baseline scan (tumor SUVmax less than blood pool SUVmax), with tumor uptake not attributable to physiologic uptake or pitfalls, or any new malignant lesion detected on follow-up CT images independent of PSMA ligand uptake.

**Synonyms:** - Response Evaluation Criteria in Prostate-specific Membrane Antigen PET/CT 1.0 Stable Disease