Autologous Anti-CLL-1-CAR T-lymphocytes BG1805

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous T-lymphocytes expressing a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) C-type-lectin-like molecule-1 (CLL-1; CLL1; C-type lectin domain family 12 member A; CLEC12A), with potential immunomodulating and antineoplastic activities. Upon administration, the autologous anti-CLL-1-CAR T-lymphocytes BG1805 specifically target and bind to CLL-1-expressing tumor cells. This induces selective toxicity in CLL-1-expressing tumor cells. CLL-1, a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily, is overexpressed in leukemic stem cells (LSCs) and plays an important role in disease progression and relapse in myeloid malignancies.

**Synonyms:** - Autologous Anti-CLL-1-CAR T-cells BG1805 - Autologous Anti-CLL1 CAR T Cells BG1805 - Autologous Anti-CLL1 CAR-T Cells BG1805 - BG 1805 - BG-1805 - BG1805