Autologous Anti-GPC3 CAR T-lymphocytes JWAT204

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for glypican-3 (GPC3), with potential immunostimulating and antineoplastic activities. Upon administration, autologous anti-GPC3 CAR T-lymphocytes JWAT204 specifically target and bind to GPC3-expressing tumor cells, resulting in tumor cell lysis. GPC3, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed in normal, healthy cells; GPC3 plays an important role in cellular proliferation and differentiation.

**Synonyms:** - Autologous Anti-GPC3 CAR T Cells JWAT204 - Autologous Anti-GPC3 CAR T-cells JWAT204 - Autologous CAR-GPC3 T Cells JWAT204 - Autologous GPC3-directed CAR-T Cells JWAT204 - JWAT 204 - JWAT-204 - JWAT204