Crisaborole Ointment

**Semantic type:** Pharmacologic Substance

**Definition:** A topical ointment formulation composed of crisaborole, a boron-containing phosphodiesterase 4 (PDE4) inhibitor, with potential immunomodulating activity. Upon topical administration of the crisaborole ointment to the affected area(s), crisaborole targets, binds to and inhibits PDE4, which increases intracellular cyclic adenosine monophosphate (cAMP) levels. This decreases inflammation in the skin. PDE4 inhibition may reduce cetuximab-related skin toxicity and atopic dermatitis.

**Synonyms:** - Eucrisa