MITF Pathway-Activated Melanocytic Tumor

**Semantic type:** Neoplastic Process

**Definition:** A cutaneous neoplasm associated with MITF gene rearrangement and either ACTIN-MITF translocation or MITF-CREM translocation. It is composed of large cells with clear cytoplasm that exhibit melanocytic differentiation and proliferate in the dermis. It presents as a single non-pigmented cutaneous nodule.

**Synonyms:** - MITF Pathway-Activated Melanocytic Neoplasm - Skin MITF Pathway-Activated Melanocytic Tumor