ACTB/MITF Fusion Gene

**Semantic type:** Gene or Genome

**Definition:** A fusion gene that results from a chromosomal rearrangement involving the short arms of chromosomes 7 (7p) and 3 (3p) that fuses the first 3 exons of the ACTB gene in frame with exon 3 of the MITF gene. This fusion is associated with a subset of clear cell neoplasms with melanocytic differentiation characterized by MITF pathway activation.

**Synonyms:** - ACTB-MITF Fusion Gene - ACTB::MITF Fusion Gene - Actin Beta-Melanocyte Inducing Transcription Factor Fusion Gene - Actin Beta::Melanocyte Inducing Transcription Factor Fusion Gene