ACTG1/MITF Fusion Gene

**Semantic type:** Gene or Genome

**Definition:** A fusion gene that results from a chromosomal translocation t(3;17)(p14;q25) that fuses the first 3 exons of the ACTG1 gene in frame with exon 3 or 4 of the MITF gene. This fusion is associated with a subset of clear cell neoplasms with melanocytic differentiation characterized by MITF pathway activation. Expression of this fusion may also be associated with a subset of clear cell renal carcinoma.

**Synonyms:** - ACTG1-MITF Fusion Gene - ACTG1::MITF Fusion Gene - Actin Gamma 1-Melanocyte Inducing Transcription Factor Fusion Gene - Actin Gamma 1::Melanocyte Inducing Transcription Factor Fusion Gene