MITF/CREM Fusion Gene

**Semantic type:** Gene or Genome

**Definition:** A fusion gene that results from a chromosomal translocation involving the short arms of chromosomes 3 (3p) and 10 (10p) that fuses the first 6 exons of the MITF gene in frame with exon 6 or 7 of the CREM gene. This fusion is associated with a subset of clear cell neoplasms with melanocytic differentiation characterized by MITF pathway activation.

**Synonyms:** - MITF-CREM Fusion Gene - MITF::CREM Fusion Gene - Melanocyte Inducing Transcription Factor-cAMP Responsive Element Modulator Fusion Gene - Melanocyte Inducing Transcription Factor::cAMP Responsive Element Modulator Fusion Gene