Methylation-Sensitive Restriction Enzyme Sequencing

**Semantic type:** Molecular Biology Research Technique

**Definition:** A method to study DNA methylation. Genomic DNA is separately digested with different methylation sensitive restriction enzymes and the fragments are used to generate a library. Deep sequencing of the library allows for accurate detection of methylation sites in the genome.

**Synonyms:** - MRE-Seq - MRE-Seq