Tethered Chromatin Conformation Capture Sequencing

**Semantic type:** Molecular Biology Research Technique

**Definition:** A method for genome-wide mapping of chromatin interactions. It is similar to Hi-C sequencing except that the ligations are performed on a solid substrate rather than in solution. This enhances the signal-to-noise ratio, thereby facilitating a detailed analysis of interactions within and between chromosomes.

**Synonyms:** - TCC Sequencing