Low-CSD Melanoma, Superficial Spreading Melanoma Subtype

**Semantic type:** Neoplastic Process

**Definition:** A cutaneous melanoma that develops on sun exposed sites with low cumulative sun damage (CSD). It is characterized by a prominent junctional and intraepidermal component with intraepidermal proliferation of individual atypical melanocytes and formation of nests of atypical melanocytes along the dermal-epidermal junction. The dermal component is composed of atypical melanocytes that fail to mature. The atypical melanocytes have large nuclei, prominent nucleoli, and eosinophilic or lightly pigmented cytoplasm. It is the most common melanoma subtype in the Western world.

**Synonyms:** - Cutaneous Superficial Spreading Melanoma - Low-CSD Melanoma, SSM Subtype - Low-CSD Melanoma, Superficial Spreading Melanoma - Low-CSD Melanoma, Superficial Spreading Melanoma (SSM) - Low-CSD Melanoma/SSM - Low-CSD Melanoma/Superficial Spreading Melanoma - Pagetoid Melanoma - SSM - Superficial Spreading Cutaneous (Skin) Melanoma - Superficial Spreading Melanoma - Superficial Spreading Melanoma - Superficial Spreading Melanoma of the Skin - Superficial spreading melanoma