Anti-ROR1/Anti-CD3/Anti-HSA Trispecific Antibody NM32-2668

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A trispecific antibody directed against the tumor-associated antigen (TAA) receptor tyrosine kinase-like orphan receptor 1 (ROR1), the T-cell surface antigen CD3 and human serum albumin (HSA), with potential immunostimulating and antineoplastic activities. Upon administration, anti-ROR1/anti-CD3/anti-HSA trispecific antibody NM32-2668 binds to both ROR1 expressed on tumor cells and CD3 expressed on cytotoxic T-lymphocytes (CTLs). This activates and redirects CTLs to ROR1-expressing tumor cells, which results in the CTL-mediated death of ROR1-expressing tumor cells. Anti-ROR1/anti-CD3/anti-HSA trispecific antibody NM32-2668 also binds to HSA, which prolongs the half-life of the agent. ROR1, also known as neurotrophic tyrosine kinase, receptor-related 1 (NTRKR1), is expressed during embryogenesis and in many types of hematological malignancies. It plays key roles in tumor cell proliferation and survival.

**Synonyms:** - Anti-ROR1/CD3/HSA Trispecific Antibody NM32-2668 - NM32 2668 - NM32-2668 - NM322668 - ROR1 x CD3 x HSA T-cell Engager NM32-2668 - ROR1 x CD3 x HSA TCE NM32-2668 - ROR1 x CD3 x HSA Trispecific Antibody NM32-2668 - ROR1-targeting TCE NM32-2668