ATTR Amyloidosis

**Semantic type:** Disease or Syndrome

**Definition:** A disorder caused by changes in the structure of transthyretin protein, affecting its ability to form tetramers. The tetramers break down and form strands of amyloid fibrils. The fibrils clump together and form amyloid deposits in tissues, causing irreversible damage. It can be hereditary, caused by mutations in the TTR gene or age-related.

**Synonyms:** - Transthyretin Amyloidosis