HMGN Family Gene

**Semantic type:** Gene or Genome

**Definition:** Human HMGN Family Genes encode nuclear HMGN proteins that bind to nucleosomes, change chromatin architecture, and enhance transcription or replication. They typically contain a Nucleosome Binding Domain that anchors these proteins to nucleosome cores to facilitate changes in higher order chromatin structure. HMGN chromatin association is dynamic and regulated by posttranslational modification; related to cell cycle and transcriptional events. (NCI)

**Synonyms:** - High Mobility Group N Gene Family