Mitogen-Activated Protein Kinase Kinase Kinase 8

**Semantic type:** Amino Acid, Peptide, or Protein|Enzyme

**Definition:** Mitogen-activated protein kinase kinase kinase 8 (467 aa, ~58 kDa) is encoded by the human MAP3K8 gene. This protein plays a role in T cell activation and serine/threonine phosphorylation.

**Synonyms:** - C-COT - COT Gene Product - COT Proto-Oncogene Serine/Threonine-Protein Kinase - Cancer Osaka Thyroid Oncogene Protein - EC 2.7.11.25 - Ewing Sarcoma Transformant - MAP Kinase Kinase Kinase 8 - MAP3K8 - MAP3K8 Kinase - Proto-Oncogene c-Cot - Serine/Threonine-Protein Kinase Cot - TPL-2 - Tpl2 - Tumor Progression Locus 2