Salmonella enterica serovar Typhi ZH9

**Semantic type:** Bacterium|Pharmacologic Substance

**Definition:** A formulation containing a live-attenuated strain of the bacterium Salmonella typhi, with potential immunomodulating and antineoplastic activities. Upon administration of Salmonella enterica serovar Typhi ZH9, the Salmonella in ZH9 may cause a Salmonella-induced systemic reprogramming of myeloid cells within the tumor microenvironment (TME). This enhances the recruitment of innate and adaptive immune cells, including the upregulation of co-stimulatory and major histocompatibility (MHC) molecules on dendritic cells (DCs), natural killer (NK) cells, CD4+ and CD8+ T-cells, monocytes, and macrophages. This may alleviate immune suppression, restore immune fitness and tissue immunosurveillance and re-activate an anti-tumor immune response.

**Synonyms:** - M01ZH 09 - M01ZH-09 - M01ZH09 - ZH 9 - ZH-9 - ZH9