SCNN1B wt Allele

**Semantic type:** Gene or Genome

**Definition:** Human SCNN1B wild-type allele is located in the vicinity of 16p12.2 and is approximately 103 kb in length. This allele, which encodes amiloride-sensitive sodium channel subunit beta protein, is involved in maintaining electrolyte, blood pressure and airway surface fluid homeostasis. Mutations in the gene are associated with Liddle syndrome type 1, bronchiectasis with or without elevated sweat chloride type 1 and autosomal recessive pseudohypoaldosteronism type 1B2.

**Synonyms:** - Amiloride-Sensitive Sodium Channel Subunit Beta 1 Gene - BESC1 - ENaCb - ENaCbeta - Epithelial Sodium Channel Beta-2 Subunit Gene - Epithelial Sodium Channel Beta-3 Subunit Gene - LIDLS1 - Liddle Syndrome Gene - Nasal Epithelial Sodium Channel Beta Subunit Gene - PHA1B2 - SCNEB - Sodium Channel Epithelial 1 Beta Subunit Gene - Sodium Channel Epithelial 1 Subunit Beta wt Allele - Sodium Channel, Epithelial 1, Beta Subunit Gene - Sodium Channel, Epithelial, Beta Subunit Gene - Sodium Channel, Non Voltage Gated 1 Beta Subunit Gene - Sodium Channel, Non-Voltage-Gated 1, Beta Subunit Gene - Sodium Channel, Nonvoltage-Gated 1, Beta Subunit Gene - beta-ENaC - beta-NaCH