HOX Pathway Mutation

**Semantic type:** Cell or Molecular Dysfunction

**Definition:** A change in the sequence of one or more genes that are involved in the signaling pathways that regulate either the expression of homeobox (HOX) family genes or transcription factor activity of HOX proteins. HOX gene expression is crucial for spatial and temporal regulation of transcription needed for embryonic development and hematopoiesis; mutations that dysregulate expression or transcription factor activities of HOX proteins are associated with oncogenesis.

**Synonyms:** - HOX Family Pathway Mutation - HOX Gene Family Pathway Mutation - Homeobox Family Pathway Mutation - Homeobox Gene Family Pathway Mutation