Allogeneic Hypoimmune Anti-CD22 CAR T-cells SC262

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of human allogeneic CD4+ and CD8+ T-lymphocytes transduced with a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) CD22, and ex vivo modified to disrupt the expression of major histocompatibility (MHC) class I and MHC class II molecules and to express CD47, with potential immunomodulating and antineoplastic activities. Upon introduction into the patient, the allogeneic hypoimmune anti-CD22 CAR T-cells SC262 recognize and bind to CD22-expressing tumor cells. This may result in a specific cytotoxic T-lymphocyte (CTL)-mediated killing of CD22-positive tumor cells. CD22, a B-lineage-restricted, transmembrane phosphoglycoprotein, is expressed on malignant B-cells. The disruption of MHC class I and MHC class II molecules and the expression of CD47 prevent both innate and adaptive immune responses against the allogeneic CAR T-cells, thereby increasing the persistence of the CAR T-cells.

**Synonyms:** - Allogeneic Anti-CD22 CAR T Cells SC262 - Allogeneic HIP Anti-CD22 CAR-T Cells SC262 - Allogeneic Hypoimmune CD22-directed CAR T-cells SC262 - Hypoimmune-modified CD22-directed Allogeneic CAR-T Cells SC262 - SC 262 - SC-262 - SC262