Zopapogene Imadenovec

**Semantic type:** Pharmacologic Substance

**Definition:** An off-the-shelf (OTS) cancer vaccine comprised of a genetically engineered, replication-deficient gorilla-derived adenovirus encoding human papillomavirus (HPV) types 6 and 11, with potential immunostimulating and antineoplastic activities. Upon administration of zopapogene imadenovec, the adenovirus infects and expresses the HPV-6/11 proteins. The expressed proteins stimulate the host immune system to produce antigen-specific neutralizing antibodies and to mount a cytotoxic T-lymphocyte (CTL) response against cells infected with HPV-6/11, thereby inducing tumor cell lysis. HPV6/11 play a key role in the development of recurrent respiratory papillomatosis (RRP).

**Synonyms:** - Gorilla-derived Adenovirus-expressing HPV-6/11 Vaccine PRGN-2012 - PRGN 2012 - PRGN-2012 - PRGN2012 - Papzimeos - Therapeutic Cancer Vaccine PRGN-2012 - ZOPAPOGENE IMADENOVEC