Glycine Receptor Complex

**Semantic type:** Amino Acid, Peptide, or Protein|Receptor

**Definition:** A family of ligand-gated pentameric ion channel complexes where the five subunits surround a central pore composed of 2 to 5 ligand-binding transmembrane alpha subunits associated with 0 to 3 beta subunits. Glycine receptors (GlyRs) are ionotropic receptors that regulate chloride transport upon binding to the amino acid neurotransmitter glycine. Other ligands include other small amino acids, such as alanine, proline, serine, sarcosine and taurine; while quercetin, caffeine and strychnine are some of the small molecule antagonists for GlyRs.

**Synonyms:** - GLR - GLYCINE RECEPTOR - GLYR - GlyR - GlyR - Glycine Receptor - Strychnine-Sensitive GlyR - Strychnine-Sensitive Glycine Receptor