Anti-MUC16 CAR T-cells 27T51

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) human mucin-16 (MUC16, cancer antigen 125; CA125; FLJ14303), with potential immunostimulating and antineoplastic activities. Upon administration, anti-MUC16 CAR T-cells 27T51 recognize and bind to MUC16-expressing tumor cells, thereby inducing selective toxicity in MUC16-expressing tumor cells. MUC16, a member of the mucin family of glycoproteins, is overexpressed on a variety of cancer cell types.

**Synonyms:** - 27T51 - Anti-MUC16 CAR T Cells 27T51 - Anti-MUC16 CAR-T Cells 27T51 - Anti-mucin-16 CAR T-cells 27T51 - bbT 4015 - bbT-4015 - bbT4015