Solute Carrier Family 12 Member 1

**Semantic type:** Amino Acid, Peptide, or Protein

**Definition:** Solute carrier family 12 member 1 (1099 aa, ~121 kDa) is encoded by the human SLC12A1 gene. This protein is involved in cotransport of sodium-potassium-chloride in renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa.

**Synonyms:** - Bumetanide-Sensitive Sodium-(Potassium)-Chloride Cotransporter 2 - Kidney-Specific Na-K-Cl Symporter - SLC12A1