Liposomal Chk1 Inhibitor SMP-3124 SMP-3124LP

**Semantic type:** Pharmacologic Substance

**Definition:** A liposomal formulation containing an inhibitor of checkpoint kinase 1 (chk1), with potential antineoplastic and chemosensitization activities. Upon administration of liposomal chk1 inhibitor SMP-3124 SMP-3124LP, SMP-3124 selectively targets and binds to chk1, thereby preventing activity of chk1 and abrogating the repair of damaged DNA. This may lead to an accumulation of damaged DNA, inhibition of cell cycle arrest, and induction of apoptosis. Chk1, an ATP-dependent serine/threonine kinase, is activated by DNA damage response and mediates cell cycle checkpoint control. It is essential for DNA repair and plays a key role in resistance to chemotherapeutic agents.

**Synonyms:** - Liposomal Chk1 Inhibitor SMP-3124 - Liposomal SMP 3124 - Liposomal SMP-3124 - Liposomal SMP3124 - SMP 3124LP - SMP-3124LP - SMP3124LP