Belladonna Alkaloids/Opium Suppository

**Semantic type:** Pharmacologic Substance

**Definition:** A combination preparation and suppository-based formulation containing belladonna extract, primarily made up of the alkaloids atropine and scopolamine, and the opioid agonist opium, produced by the poppy plant Papaver somniferum, with anti-spasmodic and analgesic activities. Upon rectal administration of the belladonna alkaloids/opium suppository, the belladonna alkaloids bind to and block muscarinic receptors in the bladder. This relaxes the smooth muscle and leads to a decrease in bladder spasms. The opium component, mainly morphine, binds to the mu-receptors in the central nervous system (CNS), thereby mimicking the effects of endogenous opioids leading to an analgesic effect.

**Synonyms:** - Atropa Belladonna and Opium Suppository - Belladonna and Opium Suppository - Belladonna/Opium Rectal Formulation - Belladonna/Opium Suppository - Opium and Belladonna Suppository