V(D)J Recombination

**Semantic type:** Genetic Function

**Definition:** Any process of gene rearrangement in which the original variable and joining region coding segments of the immunoglobulin and T cell receptor genes are ligated to create a novel protein-coding capacity. This process may occur with inclusion of the diversity coding segment to create a V(D)J coding gene. V(D)J recombination is involved in generation of diversity for both antibody and T cell receptor responses.

**Synonyms:** - Immunoglobulin V(D)J Rearrangement - V(D)J Rearrangement