Anti-MSLN/Anti-CD3 Bispecific Antibody ZW171

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A bispecific T-cell engager (TCE) and bispecific antibody directed against both the tumor-associated antigen (TAA) mesothelin (MSLN) and the T-cell surface antigen CD3, with potential immunostimulating and antineoplastic activities. Upon administration, anti-MSLN/anti-CD3 bispecific antibody ZW171 bivalently binds to MSLN expressed on tumor cells and monovalently binds to CD3 expressed on cytotoxic T-lymphocytes (CTLs). This activates and redirects CTLs to MSLN-expressing tumor cells, which results in the CTL-mediated death of MSLN-expressing tumor cells. MSLN, a cell surface glycoprotein involved in cell adhesion, is overexpressed in a variety of cancer cell types.

**Synonyms:** - Anti-MSLN/CD3 T-cell Engaging Bispecific Antibody ZW171 - Anti-mesothelin/Anti-CD3 Bispecific Antibody ZW171 - MSLN x CD3 2 +1 Bispecific Antibody ZW171 - MSLN-targeting T-cell Engager ZW171 - TCE ZW171 - ZW 171 - ZW-171 - ZW171