Anti-CD20/Anti-CD3/Anti-CD8 Trispecific Antibody AZD5492

**Semantic type:** Amino Acid, Peptide, or Protein|Immunologic Factor|Pharmacologic Substance

**Definition:** A trispecific immunoglobulin G (IgG)-like T-cell engaging (TCE) antibody targeting the tumor-associated antigen (TAA) CD20 and the T-cell surface antigens CD3 and CD8, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD20/anti-CD3/anti-CD8 trispecific antibody AZD5492 targets and binds to CD20 on CD20-expressing tumor B-cell, and the CD3 and CD8 antigens on CD8-positive T-lymphocytes. The resulting cross-linkage may trigger a potent cytotoxic T-lymphocyte (CTL) response against CD20-expressing tumor cells. CD20, a B-cell-specific cell surface antigen, is overexpressed in B-cell lineage malignancies.

**Synonyms:** - AZD 5492 - AZD-5492 - AZD5492 - CD8/TCR-based CD20-targeting T-cell Engaging Antibody AZD5492 - T-cell Engager AZD5492 - T-cell Engaging Antibody AZD5492 - TCE AZD5492 - Triple-specific Antibody AZD5492