Vincristine Liposomal

**Semantic type:** Organic Chemical|Pharmacologic Substance

**Definition:** A liposomal formulation of Vincristine designed to reduce toxicity and improve efficacy. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. (NCI)

**Synonyms:** - Lipid-Encapsulated Vincristine - Liposomal Vincristine - Onco TCS - VincaXome - Vincacine - Vincristine Liposome - Vincristine liposomal - Vincristine, Liposomal