Prognostic Liver Secretome Signature

**Semantic type:** Functional Concept

**Definition:** A non-invasive prognostic tool used predict the risk of hepatocellular carcinoma (HCC) based on the levels of expression of 8 proteins in blood or serum samples. The protein expression panel is comprised of six high risk markers: vascular cell adhesion protein 1 (VCAM1), insulin-like growth factor-binding protein 7 (IGFBP7), interleukin-6 receptor subunit beta (IL6ST; gp130), matrilysin (MMP7), interleukin-6 (IL6), and C-C motif chemokine 21 (CCL21); and two low risk markers: angiogenin (ANG) and vitamin K-dependent protein S (PROS1).

**Synonyms:** - PLSec - PLSec Signature - Prognostic Liver Secretome