Anti-B7-H3/Topoisomerase-1 Inhibitor Antibody-drug Conjugate BGB-C354

**Semantic type:** Pharmacologic Substance

**Definition:** An antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against the immunoregulatory protein B7-homologue 3 (B7-H3, CD276) conjugated to an as of yet undisclosed topoisomerase-1 inhibitor, with potential antineoplastic activity. Upon administration of anti-B7-H3/topoisomerase-1 inhibitor ADC BGB-C354, the antibody moiety targets and binds to B7-H3-expressing tumor cells. Upon binding and internalization, the topoisomerase-1 inhibitor is released and inhibits DNA topoisomerase I activity, thereby inhibiting DNA replication and resulting in cell cycle arrest and apoptosis in tumor cells expressing B7-H3. B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain tumor cell types and on various immune cells. It is a negative regulator of T-cell activation, and its overexpression plays a key role in tumor cell invasion and metastasis.

**Synonyms:** - ADC BGB-C354 - Anti-B7-H3/Topoisomerase-1 Inhibitor ADC BGB-C354 - Anti-CD276 ADC BGB-C354 - Antibody-drug Conjugate BGB-C354 - BGB C354 - BGB-C354 - BGBC354