Allogeneic Gamma-delta T-lymphocytes KB-GDT-01

**Semantic type:** Cell|Pharmacologic Substance

**Definition:** An off-the-shelf (OTS) preparation of unmodified, donor-derived T-lymphocytes that express only gamma chain and delta chain T-cell receptors (TCRs), with potential immunomodulating and antineoplastic activities. Upon administration of the allogeneic gamma-delta T-lymphocytes KB-GDT-01, these cells secrete interferon-gamma (IFN-g) and exert direct killing of tumor cells. In addition, these cells activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against tumor cells. Gamma-delta T-lymphocytes play a key role in the activation of the immune system and do not require major histocompatibility complex (MHC)-mediated antigen presentation to exert their cytotoxic effect.

**Synonyms:** - Allogeneic Gamma Delta T-cells KB-GDT-01 - Allogeneic Gamma-delta T Lymphocytes KB-GDT-01 - Allogeneic Gamma-delta T-cells KB-GDT-01 - Deltacel - Deltacel (TM) - Donor-derived Gamma Delta T-cells KB-GDT-01 - KB-GDT 01 - KB-GDT-01 - KB-GDT01